Pathophysiological Mechanisms and Multimodal Therapeutic Strategies in Meniere’s Disease

Jialin Jiang

doi:10.54254/2753-8818/2025.LD25952

Theoretical and Natural ScienceOpen access

Pathophysiological Mechanisms and Multimodal Therapeutic Strategies in Meniere’s Disease

Research Article

Open Access

Pathophysiological Mechanisms and Multimodal Therapeutic Strategies in Meniere’s Disease

Jialin Jiang ^1*

¹ Torrey Pines High School

^*Corresponding author: jiangjjy00@gmail.com

Published on 13 August 2025

TNS Vol.122

ISSN (Print): 2753-8826

ISSN (Online): 2753-8818

ISBN (Print): 978-1-80590-269-0

ISBN (Online): 978-1-80590-270-6

Download Cover

Abstract

Meniere's disease is a long-term inner ear condition that leads to vertigo, hearing loss, and tinnitus. It affects primarily women between the ages of 40 and 60 years. It is hard to treat due to its numerous causes. Research has indicated that issues like fluid buildup in the inner ear, immune system attacks, and reduced blood flow could all play a role. Diagnostic tests like vascular endothelial function testing (VEMP), electrocorticography (ECoG), and 3T magnetic resonance imaging (MRI) can assist, but all have drawbacks and are frequently utilized together. Treatment strategies encompass diuretic therapy, intratympanic injections, vestibular rehabilitation, neuromodulation, and immunomodulatory interventions. However, no single modality has proven universally effective; physicians must therefore implement individualized, combination-based treatment regimens. This review delineates the principal pathogenic mechanisms of Meniere’s disease and critically evaluates a range of therapeutic approaches, highlighting the importance of personalized treatment algorithms and multidisciplinary care models to optimize patient outcomes in Meniere’s disease management.

Keywords:

Meniere’s disease, endolymphatic hydrops, immune inflammation, microcirculation, multimodal therapy

View PDF

References

[1]. Van Esch, B. F., Van Der Zaag-Loonen, H. J., Bruintjes, T. D., Kuijpers, T., & Van Benthem, P. P. G. (2022). Interventions for Menière’s disease: An umbrella systematic review. BMJ Evidence-Based Medicine, 27(4), 235–245.

[2]. Mohseni-Dargah, M., Falahati, Z., Pastras, C., Khajeh, K., Mukherjee, P., Razmjou, A., ... & Asadnia, M. (2023). Meniere’s disease: Pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder. Environmental Research, 238, 116972.

[3]. Nakashima, T., Pyykkö, I., Arroll, M. A., Casselbrant, M. L., Foster, C. A., Manzoor, N. F., & Meniere’s Disease Research Group. (2020). Meniere’s disease. Nature Reviews Disease Primers, 6, 74-86.

[4]. Chari, D., Wu, M., Patel, A., & Lee, Y. J. (2025). A modern conceptual framework for study and treatment of Meniere’s disease. Journal of Otology and Neurotology Research, 58(1), 12-26.

[5]. Kitahara, T., Takeda, N., Tsukada, K., & Kubo, T. (2020). Recent insights into the pathophysiology of Meniere’s disease: Role of aquaporins and vasopressin. Journal of Vestibular Research, 30(2), 101-108.

[6]. Kitahara, T., Doi, K., Maekawa, C., Okayasu, T., Kizaki, H., & Horii, A. (2008). Meniere’s disease and endolymphatic hydrops: Pathophysiological significance of aquaporins in the inner ear. European Archives of Oto-Rhino-Laryngology, 265(1), 13-17

[7]. Nakashima, T., Naganawa, S., Pyykkö, I., Gibson, W. P. R., Casselman, J., & Fukushima, M. (2009). Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Oto-Laryngologica Supplementum, 129(sup560), 5-8.

[8]. Webster, K. E., Galbraith, K., Harrington-Benton, N., Judd, O., Kaski, D., Maarsingh, O. R., ... & Burton, M. J. (2023). Systemic pharmacological interventions for Menière’s disease. Cochrane Database of Systematic Reviews, 2023(2), CD011571.

[9]. Zhu, J., Wang, L., Chen, Y., & Liu, H. (2024). Comparative efficacy of intratympanic gentamicin and corticosteroids for Meniere’s disease: A systematic review and meta-analysis. Otology & Neurotology, 45(3), 218-227.

[10]. Webster, K. E., George, B., Galbraith, K., Harrington-Benton, N., Judd, O., Kaski, D., ... & Burton, M. J. (2023). Positive pressure therapy for Ménière’s disease. Cochrane Database of Systematic Reviews, 2023(2), CD015248.

References

[4]. Chari, D., Wu, M., Patel, A., & Lee, Y. J. (2025). A modern conceptual framework for study and treatment of Meniere’s disease. Journal of Otology and Neurotology Research, 58(1), 12-26.

Cite this article

Jiang,J. (2025). Pathophysiological Mechanisms and Multimodal Therapeutic Strategies in Meniere’s Disease. Theoretical and Natural Science,122,20-25.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

About volume

Volume title: Proceedings of ICBioMed 2025 Symposium: Computational Modelling and Simulation for Biology and Medicine

ISBN: 978-1-80590-269-0(Print) / 978-1-80590-270-6(Online)

Editor: Alan Wang, Roman Bauer

Conference website: https://2025.icbiomed.org/london.html

Conference date: 19 September 2025

Series: Theoretical and Natural Science

Volume number: Vol.122

ISSN: 2753-8818(Print) / 2753-8826(Online)

© 2024 by the author(s). Licensee EWA Publishing, Oxford, UK. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. Authors who publish this series agree to the following terms:

1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.

2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.

3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open access policy for details).