Research Progress on Preparation Technology and Application of Coenzyme Q10Delivery System
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Research Progress on Preparation Technology and Application of Coenzyme Q10Delivery System

Youyao Luo 1*
1 School of Chemistry and Materials Science, Langfang Normal University, Langfang, Hebei, 065000, China
*Corresponding author: lfsfxyxinxigongkai@126.com
Published on 30 July 2025
Volume Cover
TNS Vol.133
ISSN (Print): 2753-8826
ISSN (Online): 2753-8818
ISBN (Print): 978-1-80590-303-1
ISBN (Online): 978-1-80590-304-8
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Abstract

Coenzyme Q10is a lipid-soluble quinone compound that functions both as a mitochondrial electron transport carrier and as an antioxidant. It is widely used in the fields of cardiovascular disease adjuvant therapy, health products, and cosmetics. However, its poor water solubility, low photothermal stability, and limited bioavailability constrain its practical applications. This paper systematically discusses three delivery systems for coenzyme Q10: nanoemulsions, which enhance water solubility and cellular permeability; nanoparticles, which enable particle size control and high encapsulation efficiency with targeted, sustained-release properties; and gel-based delivery systems, which improve the skin’s antioxidant capacity and storage stability. This research offers material design strategies and technological optimization approaches to address the bottlenecks in coenzyme Q10application, providing important academic reference value for improving the bioavailability of lipophilic active substances.

Keywords:

Coenzyme Q10, Nano emulsion, Nanoparticles, Gel-based delivery system, Bioavailability.

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Luo,Y. (2025). Research Progress on Preparation Technology and Application of Coenzyme Q10Delivery System. Theoretical and Natural Science,133,29-35.

References

[1]. Gong Nengyun, Hu Shiran, Zhu Mengjia, etc The lipid-lowering effect of Antarctic krill oil in combination with red yeast and coenzyme Q10 [J/OL]. Food Industry Technology, 1-30 [June 7, 2025] https: //doi.org/10.13386/j.issn1002-0306.2024120141.

[2]. Zhu Mengjie, Fang Suqiong, Xu Jun, Wu Jian, Miao Jinyu, Ma Li, Liu Wei, Zou Liqiang. Preparation, characterization, and improvement of biological acceptability of crystal regulated coenzyme Q10 nanostructured lipid carriers [J/OL]. Food and Fermentation Industry https: //doi.org/10.13995/j.cnki.11-1802/ts.041950

[3]. Zhang Ziyu, Gao Qing, Li Wenzhe, etc Development and transdermal performance evaluation of coenzyme Q10 nanoemulsion [J]. Journal of Shenyang Pharmaceutical University, 2021, 38 (07): 656-662. DOI: 10.14066/j.cnki. cn21-1349/r.2019.1346

[4]. Chen Jinping, Song Quanwen Mutation breeding and genetic stability study of high producing strains of coenzyme Q10 as a food additive [J]. Chinese and Foreign Food Industry, 2025, (06): 49-51

[5]. Yang Yaxuan, Hua Yu, Chen Si, etc Research progress on coenzyme Q10 liposomes [J]. Grain and Oil, 2025, 38 (03): 14-20

[6]. Wang Zhongjuan, Li Zihan, Zhang Xiujuan, etc Preparation, characterization, and pharmacokinetic study of coenzyme Q10 nanoemulsion based on Pinus koraiensis seed oil [J]. Food Industry Science and Technology, 2022, 43 (21): 225-234. DOI: 0.13386/j.issn1002-0306.202202008

[7]. Zhou Ben, Fan Yanrong Preparation and performance study of coenzyme Q10 nano emulsion [J]. Pharmaceutical Biotechnology, 2021, 28 (06): 561-568. DOI: 10.19526/j.cnki.1005-8915.20210602

[8]. Huang Juan, Wang Yunjuan, Bai Hua, etc Preparation and characterization of mixed flaxseed oil and coenzyme Q10 emulsion [J]. Journal of Agricultural Engineering, 2020, 36 (06): 292-299

[9]. Zhou Ben Preparation and characterization of coenzyme Q10 nano emulsion [D]. Nanjing University of Science and Technology, 2021. DOI: 10.27241/d.cnki.gnjgu.2021.003289

[10]. Yang Yang, Shi Ruijie, Li Mingzhong, Xiao Aiai, Wu Hengqian, Cai Jinyi, Wang Zhengping. Process optimization of coenzyme Q10 nanoemulsion and study on its antioxidant activity and in vivo bioavailability [J/OL]. Journal of Liaocheng University (Natural Science Edition) https: //doi.org/10.19728/j.issn1672-6634.2025010020

[11]. Li Fei Preparation and characterization of coenzyme Q10 nanocapsules based on nano emulsion technology [D]. South China University of Technology, 2023. DOI: 10.27151/d.cnki.ghnlu.2023.001744

[12]. Zhou Sanjiu, He Shenghua Effect of SSPs and pea protein on the stability of coenzyme Q10 emulsion [j]. Journal of Xuchang University, 2025, 44 (02): 66-70

[13]. Yu Yijing, Ma Li Construction and characterization of coenzyme Q10 loaded nanoparticles [J/OL]. Food and Fermentation Industry, 1-11 [2022-06-17] https: //doi.org/10.13995/j.cnki.11-1802/ts.040414.

[14]. Banun V J, Rewatkar P, Chaudhary Z, et al. Protein nanoparticles for enhanced oral delivery of coenzyme-Q10: in vitro and in silico studies [J]. ACS Biomaterials Science & Engineering, 2021, 9(6): 2846-2856.

[15]. Zhang Xiaoxue, Zhao Xiuhua, Liu Yanjie, etc Preparation and bioavailability of coenzyme Q10/amphiphilic xylan nanosuspension [J]. Plant Research, 2020, 40 (06): 943-950

[16]. Wang Tong, Yang Ruinan, Meng Pengcheng, etc Construction of cottonseed oil stearin monoglyceride based oil gel and its application in biscuits [J/OL]. China Grease, 1-10 [2025-06-21] http: //kns.cnki.net/kcms/detail/61.1099.TS.20250529.1532.002.html.

[17]. Qu Yanfeng, Liu Luoming, Kong Zhen, etc Research progress in preparation of oil gel and its application in food [J]. Food and Machinery, 2025, 41 (03): 221-227. DOI: 10.13652/j.spjx.1003.5788.2024.81097

[18]. Zhang Yujie, Zhong Wei, Wang Zhongyan, etc Preparation and evaluation of coenzyme Q10 flexible liposome gel [J]. Journal of Shenyang Pharmaceutical University, 2024, 41 (10): 1306-1315+1331. DOI: 10.14066/j.cnki.cn21-1349/r.2023.0398

[19]. Cheng Rong Preparation and properties of coenzyme Q10 lipid vesicles and gel [D]. Hefei University of Technology, 2021. DOI: 10.27101/d.cnki.ghfgu.2021.000614

References

[1]. Gong Nengyun, Hu Shiran, Zhu Mengjia, etc The lipid-lowering effect of Antarctic krill oil in combination with red yeast and coenzyme Q10 [J/OL]. Food Industry Technology, 1-30 [June 7, 2025] https: //doi.org/10.13386/j.issn1002-0306.2024120141.

[2]. Zhu Mengjie, Fang Suqiong, Xu Jun, Wu Jian, Miao Jinyu, Ma Li, Liu Wei, Zou Liqiang. Preparation, characterization, and improvement of biological acceptability of crystal regulated coenzyme Q10 nanostructured lipid carriers [J/OL]. Food and Fermentation Industry https: //doi.org/10.13995/j.cnki.11-1802/ts.041950

[3]. Zhang Ziyu, Gao Qing, Li Wenzhe, etc Development and transdermal performance evaluation of coenzyme Q10 nanoemulsion [J]. Journal of Shenyang Pharmaceutical University, 2021, 38 (07): 656-662. DOI: 10.14066/j.cnki. cn21-1349/r.2019.1346

[4]. Chen Jinping, Song Quanwen Mutation breeding and genetic stability study of high producing strains of coenzyme Q10 as a food additive [J]. Chinese and Foreign Food Industry, 2025, (06): 49-51

[5]. Yang Yaxuan, Hua Yu, Chen Si, etc Research progress on coenzyme Q10 liposomes [J]. Grain and Oil, 2025, 38 (03): 14-20

[6]. Wang Zhongjuan, Li Zihan, Zhang Xiujuan, etc Preparation, characterization, and pharmacokinetic study of coenzyme Q10 nanoemulsion based on Pinus koraiensis seed oil [J]. Food Industry Science and Technology, 2022, 43 (21): 225-234. DOI: 0.13386/j.issn1002-0306.202202008

[7]. Zhou Ben, Fan Yanrong Preparation and performance study of coenzyme Q10 nano emulsion [J]. Pharmaceutical Biotechnology, 2021, 28 (06): 561-568. DOI: 10.19526/j.cnki.1005-8915.20210602

[8]. Huang Juan, Wang Yunjuan, Bai Hua, etc Preparation and characterization of mixed flaxseed oil and coenzyme Q10 emulsion [J]. Journal of Agricultural Engineering, 2020, 36 (06): 292-299

[9]. Zhou Ben Preparation and characterization of coenzyme Q10 nano emulsion [D]. Nanjing University of Science and Technology, 2021. DOI: 10.27241/d.cnki.gnjgu.2021.003289

[10]. Yang Yang, Shi Ruijie, Li Mingzhong, Xiao Aiai, Wu Hengqian, Cai Jinyi, Wang Zhengping. Process optimization of coenzyme Q10 nanoemulsion and study on its antioxidant activity and in vivo bioavailability [J/OL]. Journal of Liaocheng University (Natural Science Edition) https: //doi.org/10.19728/j.issn1672-6634.2025010020

[11]. Li Fei Preparation and characterization of coenzyme Q10 nanocapsules based on nano emulsion technology [D]. South China University of Technology, 2023. DOI: 10.27151/d.cnki.ghnlu.2023.001744

[12]. Zhou Sanjiu, He Shenghua Effect of SSPs and pea protein on the stability of coenzyme Q10 emulsion [j]. Journal of Xuchang University, 2025, 44 (02): 66-70

[13]. Yu Yijing, Ma Li Construction and characterization of coenzyme Q10 loaded nanoparticles [J/OL]. Food and Fermentation Industry, 1-11 [2022-06-17] https: //doi.org/10.13995/j.cnki.11-1802/ts.040414.

[14]. Banun V J, Rewatkar P, Chaudhary Z, et al. Protein nanoparticles for enhanced oral delivery of coenzyme-Q10: in vitro and in silico studies [J]. ACS Biomaterials Science & Engineering, 2021, 9(6): 2846-2856.

[15]. Zhang Xiaoxue, Zhao Xiuhua, Liu Yanjie, etc Preparation and bioavailability of coenzyme Q10/amphiphilic xylan nanosuspension [J]. Plant Research, 2020, 40 (06): 943-950

[16]. Wang Tong, Yang Ruinan, Meng Pengcheng, etc Construction of cottonseed oil stearin monoglyceride based oil gel and its application in biscuits [J/OL]. China Grease, 1-10 [2025-06-21] http: //kns.cnki.net/kcms/detail/61.1099.TS.20250529.1532.002.html.

[17]. Qu Yanfeng, Liu Luoming, Kong Zhen, etc Research progress in preparation of oil gel and its application in food [J]. Food and Machinery, 2025, 41 (03): 221-227. DOI: 10.13652/j.spjx.1003.5788.2024.81097

[18]. Zhang Yujie, Zhong Wei, Wang Zhongyan, etc Preparation and evaluation of coenzyme Q10 flexible liposome gel [J]. Journal of Shenyang Pharmaceutical University, 2024, 41 (10): 1306-1315+1331. DOI: 10.14066/j.cnki.cn21-1349/r.2023.0398

[19]. Cheng Rong Preparation and properties of coenzyme Q10 lipid vesicles and gel [D]. Hefei University of Technology, 2021. DOI: 10.27101/d.cnki.ghfgu.2021.000614

Cite this article

Luo,Y. (2025). Research Progress on Preparation Technology and Application of Coenzyme Q10Delivery System. Theoretical and Natural Science,133,29-35.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

About volume

Volume title: Proceedings of ICBioMed 2025 Symposium: AI for Healthcare: Advanced Medical Data Analytics and Smart Rehabilitation

ISBN: 978-1-80590-303-1(Print) / 978-1-80590-304-8(Online)
Editor: Alan Wang
Conference website: https://2025.icbiomed.org/auckland.html
Conference date: 17 October 2025
Series: Theoretical and Natural Science
Volume number: Vol.133
ISSN: 2753-8818(Print) / 2753-8826(Online)

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