Laser-Assisted Biofilm Disruption and Its Role in Periodontal Tissue Regeneration

Aikebaier Kaiwusaer

doi:10.54254/2753-8818/2025.AU27348

Theoretical and Natural ScienceOpen access

Laser-Assisted Biofilm Disruption and Its Role in Periodontal Tissue Regeneration

Research Article

Open Access

Laser-Assisted Biofilm Disruption and Its Role in Periodontal Tissue Regeneration

Aikebaier Kaiwusaer ^1*

¹ Urumqi Foreign Languages School

^*Corresponding author: Algieeee@outlook.com

Published on 2 October 2025

TNS Vol.139

ISSN (Print): 2753-8826

ISSN (Online): 2753-8818

ISBN (Print): 978-1-80590-395-6

ISBN (Online): 978-1-80590-396-3

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Abstract

Laser interventions in periodontology combine targeted biofilm disruption, localized photochemical antimicrobial activity, and modulation of host repair pathways. NdYAG around 1064 nm couples to hemoproteins and penetrates millimeters to enable coagulation and contactless disinfection in vascularized pockets. ErYAG near 2940 nm is absorbed by water and hydroxyapatite and ablates mineral deposits while volatilizing extracellular polymeric substances. Diode lasers from 810 to 980 nm activate porphyrin photosensitizers for photodynamic therapy and provide antimicrobial action with low thermal burden. Short high peak pulses induce photoacoustic cavitation; collapsing bubbles generate microjets and shear that detach 3D biofilm from root furcation and irregular surfaces. Photochemical activation produces singlet oxygen and radicals that oxidize membranes, nucleic acids and matrix components, enhancing antimicrobial penetration and reducing selective pressure associated with prolonged antibiotics. Subablative irradiation modulates mitochondrial redox and downstream signaling, reduces proinflammatory cytokines and promotes fibroblast proliferation, collagen deposition, osteogenic gene expression and VEGF mediated angiogenesis, effects that correspond to measurable gains in probing depth, clinical attachment level and local bone volume. This review aims to synthesize mechanistic insights and clinical considerations to guide parameter selection and future translational research.

Keywords:

Laser, periodontal biofilm, photodynamic therapy, tissue regeneration.

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References

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References

[7]. Harris, D.M. and Reinisch, L. (2016) Selective Photoantisepsis. Lasers in Surgery and Medicine, 48(8), 763–773.

[10]. Damante, C.A. (2021) Laser Parameters in Systematic Reviews. Journal of Clinical Periodontology, 48(4), 550–552.

Cite this article

Kaiwusaer,A. (2025). Laser-Assisted Biofilm Disruption and Its Role in Periodontal Tissue Regeneration. Theoretical and Natural Science,139,62-68.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

About volume

Volume title: Proceedings of ICBioMed 2025 Symposium: AI for Healthcare: Advanced Medical Data Analytics and Smart Rehabilitation

ISBN: 978-1-80590-395-6(Print) / 978-1-80590-396-3(Online)

Editor: Alan Wang

Conference website: https://2025.icbiomed.org/auckland.html

Conference date: 17 October 2025

Series: Theoretical and Natural Science

Volume number: Vol.139

ISSN: 2753-8818(Print) / 2753-8826(Online)

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