Retrosynthetic Analysis of Peniapyrone E
Research Article
Open Access
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Retrosynthetic Analysis of Peniapyrone E

Eric Wang 1*
1 Jericho Senior High School, NY, USA
*Corresponding author: agedwy@gmail.com
Published on 19 November 2025
Volume Cover
ACE Vol.208
ISSN (Print): 2755-273X
ISSN (Online): 2755-2721
ISBN (Print): 978-1-80590-547-9
ISBN (Online): 978-1-80590-548-6
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Abstract

Retrosynthesis is the increasingly used strategy of breaking down a target molecule into simpler precursor structures through strategic disconnections. It is critical in helping devise a synthetic route to a complex organic compound as it ideally fragments the original molecule into easily obtainable pieces. The goal of this paper is to provide such a plan that would open a simple synthetic pathway to the recently discovered organic molecule Penipyrone E.

Keywords:

Retrosynthesis, Retrosynthetic analysis, Peniapyrone E

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Wang,E. (2025). Retrosynthetic Analysis of Peniapyrone E. Applied and Computational Engineering,208,27-31.

References

[1]. Bai, Yan; Ma, Xiaodong; Ren, Duo; Yu, Guoqing; Hu, Jiangchun; Hua, Huiming; et al. (2024). Peniapyrones A–I, Cytotoxic Tricyclic-Fused α‑Pyrone Derivatives from an Endophytic Penicillium brefeldianum F4a. ACS Publications. Collection. https: //doi.org/10.1021/acs.jnatprod.4c00383

[2]. Ye, Y. (2023). Introductory to Organic Synthesis and Retrosynthesis Analysis. In MedScien (Vol. 1, Issue 1). Dean & Francis Press. https: //doi.org/10.61173/5s5brt52

[3]. Guo J , Yu C , Li K , et al.Retrosynthesis Zero: Self-Improving Global Synthesis Planning Using Reinforcement Learning [J].Journal of Chemical Theory and Computation, 2024, 20(11): 18.DOI: 10.1021/acs.jctc.4c00071.

[4]. El-Mernissi R , Alaqarbeh M , Khaldan A , et al.3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer [J].OPEN CHEMISTRY, 2024, 22(1).DOI: 10.1515/chem-2024-0041.

[5]. Zhong Z , Song J , Zunlei FengTiantao LiuLingxiang JiaShaolun YaoTingjun HouMingli Song.Recent advances in deep learning for retrosynthesis [J].Wiley Interdisciplinary Reviews. Computational Molecular Science, 2024, 14(1): n/a-n/a.DOI: 10.1002/wcms.1694.

Cite this article

Wang,E. (2025). Retrosynthetic Analysis of Peniapyrone E. Applied and Computational Engineering,208,27-31.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

About volume

Volume title: Proceedings of the 5th International Conference on Materials Chemistry and Environmental Engineering

ISBN: 978-1-80590-547-9(Print) / 978-1-80590-548-6(Online)
Editor: Ömer Burak İSTANBULLU
Conference website: https://2025.confmcee.org/
Conference date: 12 January 2026
Series: Applied and Computational Engineering
Volume number: Vol.208
ISSN: 2755-2721(Print) / 2755-273X(Online)