Retrosynthesis: A Strategy for Organic Synthesis

Qian Fu

doi:10.54254/2755-2721/2025.29722

Applied and Computational EngineeringOpen access

Retrosynthesis: A Strategy for Organic Synthesis

Research Article

Open Access

Retrosynthesis: A Strategy for Organic Synthesis

Qian Fu ^1*

¹ China University of Mining & Technology

^*Corresponding author: 18225220367@163.com

Published on 19 November 2025

ACE Vol.208

ISSN (Print): 2755-273X

ISSN (Online): 2755-2721

ISBN (Print): 978-1-80590-547-9

ISBN (Online): 978-1-80590-548-6

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Abstract

Retrosynthesis, method for derive reactants from the reaction products. This method uses a reverse thinking to explore the chemical synthesis problem. And this analytical method has effectively promoted the development of computer-aided organic synthesis. Retrosynthesis analysis is of great practical significance for organic chemical analysis. This paper focuses on the development situation of Retrosynthesis analysis and the current application situation and application methods of inverse synthesis analysis. The author also uses the method summarized in this article and demonstrates the application of retrosynthesis analysis with the synthesis of indole, ibuprofen, penicillin V, and morphine as practical cases. The results of this discussion on Retrosynthesis analysis are conducive to the learning of chemical analysis methods and reverse thinking, and conducive to further promote the development of big data-assisted organic synthesis, which is of practical significance.

Keywords:

organic, retrosynthesis, Organic Synthesis

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References

[1]. Corey E J, Cheng Xue-Min, The logic of chemical synthesis.John Wiley & Son, 1989.

[2]. Kurti, Laszlo; Czako, Barbara. Strategic Applications of Named Reactions in Organic Synthesis. Academic Press, 2005-3-18

[3]. Zhu Guanhua, Yu Liangmin, Zhang Qi. Investigation on the mechanism of Fischer index synthesis method and its application progress. Guangzhou Chemical Industry-2012, Issue 017

[4]. Richard A Kjonaas, Peggy E Williams, David A Counce, Lindsey R Crawley. Synthesis of ibuprofen in the introductory organic laboratory. Journal of Chemical Education 88 (6), 825-828, 2011

[5]. Ch L Cooney, F Acevedo. Theoretical conversion yields for penicillin synthesis. Biotechnology and bioengineering 19 (10), 1449-1462, 1977

[6]. Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama. Total synthesis of (±)-morphine. Organic letters 8 (23), 5311-5313, 2006

References

[1]. Corey E J, Cheng Xue-Min, The logic of chemical synthesis.John Wiley & Son, 1989.

[2]. Kurti, Laszlo; Czako, Barbara. Strategic Applications of Named Reactions in Organic Synthesis. Academic Press, 2005-3-18

[3]. Zhu Guanhua, Yu Liangmin, Zhang Qi. Investigation on the mechanism of Fischer index synthesis method and its application progress. Guangzhou Chemical Industry-2012, Issue 017

[4]. Richard A Kjonaas, Peggy E Williams, David A Counce, Lindsey R Crawley. Synthesis of ibuprofen in the introductory organic laboratory. Journal of Chemical Education 88 (6), 825-828, 2011

[5]. Ch L Cooney, F Acevedo. Theoretical conversion yields for penicillin synthesis. Biotechnology and bioengineering 19 (10), 1449-1462, 1977

[6]. Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama. Total synthesis of (±)-morphine. Organic letters 8 (23), 5311-5313, 2006

Cite this article

Fu,Q. (2025). Retrosynthesis: A Strategy for Organic Synthesis. Applied and Computational Engineering,208,32-39.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

About volume

Volume title: Proceedings of the 5th International Conference on Materials Chemistry and Environmental Engineering

ISBN: 978-1-80590-547-9(Print) / 978-1-80590-548-6(Online)

Editor: Ömer Burak İSTANBULLU

Conference website: https://2025.confmcee.org/

Conference date: 12 January 2026

Series: Applied and Computational Engineering

Volume number: Vol.208

ISSN: 2755-2721(Print) / 2755-273X(Online)

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